Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus.

Comment on "Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus".

Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood.

Lipoteichoic acid (LTA), a ubiquitous cell wall component of Gram-positive bacteria, represents a potent immunostimulatory molecule. Because LTA of a mutant Staphylococcus aureus strain lacking lipoproteins (Deltalgt-LTA) has been described to be immunobiologically inactive despite a lack of ascertained structural differences to wild-type LTA (wt-LTA), we investigated the functional requirement...

The Synthesis of Polyribitol Phosphate

The synthesis of polyribitol phosphate by polyribitol phosphate polymerase from Staphylococcus aureus H proceeds by a single chain mechanism so that the enzyme completes a chain of approximately 30 units linked to lipoteichoic acid carrier, before starting a new chain. The lipoteichoic acid carrier of Staphylococcus aweus and Bacillus subtilis are interchangeable and can be used both for the sy...

The Synthesis of Polyribitol Phosphate

The synthesis of polyribitol phosphate by polyribitol phosphate polymerase from Staphylococcus aureus H proceeds by a single chain mechanism so that the enzyme completes a chain of approximately 30 units linked to lipoteichoic acid carrier, before starting a new chain. The lipoteichoic acid carrier of Staphylococcus aweus and Bacillus subtilis are interchangeable and can be used both for the sy...

Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction.

For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compoun...